Layer V Pyramidal Cell Model With Reduced Morphology (maki-marttunen Et Al 2017)

A set of reduced models of layer 5 pyramidal neurons (Bahl et al. 2012) Free Keywords: Description: These are the NEURON files for 10 different models of a reduced L5 pyramidal neuron. The parameters were obtained by automatically fitting the models to experimental data using a multi objective evolutionary search strategy.

Throughout the nervous system, cells belonging to a certain electrical class (e-class)–sharing high similarity in firing response properties–may nevertheless have widely variable dendritic morpholo.

Layer 3 contained the only subtype that showed a burst of action potentials upon current injection. Layer 5 pyramidal neurons showed the largest voltage sags. Finally, pyramidal neurons in layer 6 (L6) showed a great variety in their morphology with 39% of L6 neurons possessing tall apical dendrites that extend into layer 1.

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We used our previously reported custom-built 2P laser scanning microscope 25,26 to obtain a 3D view of layer V (L5) cortical pyramidal cells (PCs) labelled with Alexa-488 from which we chose the.

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We evaluated the characteristics of the persistent sodium current (I NaP) in pyramidal neurons of layers II/III and V in slices of rat sensorimotor cortex using whole cell patch-clamp recordings.In both layers, I NaP began activating around −60 mV and was half-activated at −43 mV. The I NaP peak amplitude and density were significantly higher in layer V.

Model of adolescent THC exposure and approaches for layer- and cell-specific morphological and. as male rats exposed during adulthood exhibit changes in layer V pyramidal neuron morphology. Janssen WG, Ohm DT, Yuk FJ, Wadsworth S, Saardi KM, et al. Evidence for reduced experience-dependent dendritic spine plasticity in the.

Model of adolescent THC exposure and approaches for layer- and cell-specific morphological and transcriptional profiling of prelimbic (PrL) pyramidal neurons.

How to cite this article: Yi, G. et al. Action potential initiation in a two-compartment model of pyramidal neuron mediated by dendritic Ca 2+ spike. Sci. Rep. 7, 45684; doi: 10.1038/srep45684 (2017).

Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis. E. E. et al. Synapse Dysfunction of Layer V Pyramidal.

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Here, we introduce an approach for computational optogenetic modeling to test hypotheses, demonstrating it with application to the role of dendrites in neuronal gain control. We find that gain modulability is indicated by dendritic morphology, with pyramidal cell-like.